Understanding Inflammatory Pathways and How Supplements Can Help
In this video, we dive into the fascinating world of inflammation and explore the main pathways that play a crucial role in the body's response to injury or infection. We discuss the:
My article capturing this information: https://www.drbeen.com/articles/understanding-inflammatory-pathways-and-how-supplements-can-help/
Following pathways and supplements to modulate these are presented in this talk:
Arachidonic Acid Pathway
JAK-STAT Pathway
MAPK Pathway
NF-κB Pathway
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Timestamps:
0:00 - Introduction to Inflammatory Pathways
0:34 - Pathways
2:39 - Supplements
Further Reading and References:
NF-kB and Jak-STAT pathway suppression
Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways | Acta Biochimica et Biophysica Sinica | Oxford Academic
https://academic.oup.com/abbs/article/47/3/207/1754742
Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784227/
Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review - PubMed
https://pubmed.ncbi.nlm.nih.gov/32157749/
Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity1 | The Journal of Immunology | American Association of Immunologists
https://journals.aai.org/jimmunol/article/163/6/3474/32577/Curcumin-Blocks-Cytokine-Mediated-NF-B-Activation
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
Arachidonic Acid Pathway
Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537720/
MAPK Pathway
Omega-3 fatty acids mediated Cellular signaling and its regulation in Human Health - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S266726852300058X
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
,,-gsLxPagNB8,UCrtd2wePvAl6RN_D-9jWVQQ, Health,Knowledge, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_-gsLxPagNB8,What Are Reactive Oxygen Species and Lipid Species?
Let's understand the foundational components of inflammation reactive oxygen and reactive lipid species.
If you like this content and want more, I am doing a special membership offer. Click here:
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#drbeen #koolbeens #diabetes
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,,hRCac7xcAtg,UCrtd2wePvAl6RN_D-9jWVQQ, Health, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_hRCac7xcAtg,Erratum: Quercetin is primarily lipid soluble and weakly water soluble. I have put it in an incorrect category.
Which Antioxidants To Use Together?
As we use antioxidants for aches and pains/inflammation we need to keep in mind the water or lipid solubility of the molecule. Let's review.
If you like this content and want more, I am doing a special membership offer. Click here:
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#drbeen #koolbeens #diabetes
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,1,Simple Plan to Control Inflammation
Here is an important list of anti-inflammatory molecules to help manage inflammation.
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
Want to support this work?:
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#drbeen #Inflammation #Supplements
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References:
Visit articles related to these topics and see the references at the end: https://www.drbeen.com/articles/category/chronic-inflammation/
,1,Vitamin D May Reduce Fiery Death of Cells and Resulting Severe Inflammation
Vitamin D receptor activation leads to reduced pyroptosis, and a shift towards autophagy and apoptosis. Let's review the mechanism of pyroptosis and the studies about vitamin D's role in preventing pyroptosis.
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
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#drbeen #Inflammation #VitaminD
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jun. 21 2024 16:18 PM
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793783/
Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0960076020303149
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904361/
Pyroptosis: mechanisms and diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-021-00507-5
Effects of Vitamin D3 Supplementation and Aerobic Training on Autophagy Signaling Proteins in a Rat Model Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535215/
Apoptosis Induced by Vitamin D Compounds in Breast Cancer Cells Is Inhibited by Bcl-2 but Does Not Involve Known Caspases or p531 | Cancer Research | American Association for Cancer Research
https://aacrjournals.org/cancerres/article/59/19/4848/505530/Apoptosis-Induced-by-Vitamin-D-Compounds-in-Breast
Morphological Features of Organelles during Apoptosis: An Overview - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972681/
,1,Omega-3 Reduces Chronic Inflammation and Neurosurgical Pain
Two studies demonstrating the power of omega-3 to reduce inflammation and neurosurgical pain.
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
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#drbeen #koolbeens #Health #omega3
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Reference:
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - PubMed https://pubmed.ncbi.nlm.nih.gov/16531187/
An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/
Study Details | Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects | ClinicalTrials.gov https://clinicaltrials.gov/study/NCT01154478
Table - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/table/molecules-26-03369-t001/
University of Naples Federico II - Wikipedia https://en.wikipedia.org/wiki/University_of_Naples_Federico_II
,1,Understanding Inflammatory Pathways and How Supplements Can Help
In this video, we dive into the fascinating world of inflammation and explore the main pathways that play a crucial role in the body's response to injury or infection. We discuss the:
My article capturing this information: https://www.drbeen.com/articles/understanding-inflammatory-pathways-and-how-supplements-can-help/
Following pathways and supplements to modulate these are presented in this talk:
Arachidonic Acid Pathway
JAK-STAT Pathway
MAPK Pathway
NF-κB Pathway
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
My substack: https://mobeensyedmd.substack.com/
#drbeen #koolbeens #HealthPolicy
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Timestamps:
0:00 - Introduction to Inflammatory Pathways
0:34 - Pathways
2:39 - Supplements
Further Reading and References:
NF-kB and Jak-STAT pathway suppression
Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways | Acta Biochimica et Biophysica Sinica | Oxford Academic
https://academic.oup.com/abbs/article/47/3/207/1754742
Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784227/
Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review - PubMed
https://pubmed.ncbi.nlm.nih.gov/32157749/
Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity1 | The Journal of Immunology | American Association of Immunologists
https://journals.aai.org/jimmunol/article/163/6/3474/32577/Curcumin-Blocks-Cytokine-Mediated-NF-B-Activation
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
Arachidonic Acid Pathway
Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537720/
MAPK Pathway
Omega-3 fatty acids mediated Cellular signaling and its regulation in Human Health - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S266726852300058X
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
,1,This week, we're highlighting the National Labor Relations Board’s (NLRB's) crackdown on confidentiality and non-disparagement provisions in severance agreements, a U.S. Supreme Court decision opening overtime to high-earning daily-rate workers, and a U.S. Court of Appeals for the Ninth Circuit decision in favor of mandatory arbitration in California.
NLRB Cracks Down on Confidentiality and Non-Disparagement Provisions in Severance Agreements
The NLRB held in McLaren Macomb that it is an unfair labor practice for employers to include non-disparagement and confidentiality provisions in severance agreements.
Supreme Court Opens Overtime to Highly Compensated Employees
The high court has ruled that a daily-rate worker earning over $200,000 a year is entitled to overtime because he does not meet the requirements for an overtime exemption under the Fair Labor Standards Act.
Ninth Circuit Keeps Mandatory Arbitration Alive in California
The Ninth Circuit held that AB 51, which made it illegal for California employers to require employees to sign arbitration agreements, is preempted by the Federal Arbitration Act.
Other Highlights
D.C. Council Delays Increase to Tipped Minimum Wage
Wage and Hour Defense Blog
Eric I. Emanuelson Jr, Corben J. Green
https://www.wagehourblog.com/2023/03/articles/tipped-employees/d-c-council-delays-increase-to-tipped-minimum-wage/
Update: NY Governor Approves Pay Transparency Law Amendments
Workforce Bulletin
Marc A. Mandelman, Nancy Gunzenhauser Popper, Lucas Peterhans
https://www.workforcebulletin.com/2023/03/06/update-ny-governor-approves-pay-transparency-law-amendments/
Time Is Money: A Quick Wage-Hour Tip on . . . the Tip Credit
Wage and Hour Defense Blog
Eric I. Emanuelson Jr.
https://www.wagehourblog.com/2023/02/articles/tipped-employees/time-is-money-a-quick-wage-hour-tip-on-the-tip-credit/
Trade Secrets Litigation: 2023 Update
Commercial Litigation Update
Peter A. Steinmeyer
https://www.commerciallitigationupdate.com/2023/02/28/trade-secrets-litigation-2023-update/
Halting Harassment®: Online Training
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Judicial Watch President @TomFitton appeared WDEL radio to discuss the Superior Court of the State of Delaware hearing Judicial Watch's petition to reopen its case for the release of Joe Biden’s Senate records kept at the University of Delaware. LISTEN NOW!
Stay ahead of the censors - Join us warroom.org/join Aired On: 8/20/2024 Watch: On the Web: https://www.warroom.org On Gettr: @WarRoom On Podcast: Apple, iHeart Radio, Google On TV: PlutoTV Channel 240, Dish Channel 219, Roku, Apple TV, FireTV or on https://AmericasVoice.news. #news #politics #realnews
,1,Full Measure with Sharyl Attkisson is television’s most original Sunday news program. The program specializes in fearless reporting on untouchable subjects to bring you stories you won’t see anywhere else. The host is investigative journalist Sharyl Attkisson, five-time Emmy Award winner and recipient of the Edward R. Murrow award for investigative reporting. Attkisson is backed by a team of award winning journalists.
Full Measure investigates topics such as immigration at home and abroad; government waste, fraud and abuse; terrorism and national security; whistleblowers; and government and corporate misdeeds. The program is also home to unique interviews and regular features including Follow the Money and Campaign Incredible.
Full Measure is produced by and airs nationally on stations of the Sinclair Broadcast Group. It is available in 43 million households in 79 markets on 162 Sinclair stations, including ABC, CBS, NBC, FOX, CW, MyTV, Univision and Telemundo affiliates. Follow the link to find out when & where to watch in your area. http://fullmeasure.news/about#where-to-watch
The program also streams live on all Sinclair websites and at http://fullmeasure.news/ on Sundays at 9:30 a.m. ET.