Understanding Inflammatory Pathways and How Supplements Can Help
In this video, we dive into the fascinating world of inflammation and explore the main pathways that play a crucial role in the body's response to injury or infection. We discuss the:
My article capturing this information: https://www.drbeen.com/articles/understanding-inflammatory-pathways-and-how-supplements-can-help/
Following pathways and supplements to modulate these are presented in this talk:
Arachidonic Acid Pathway
JAK-STAT Pathway
MAPK Pathway
NF-κB Pathway
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Timestamps:
0:00 - Introduction to Inflammatory Pathways
0:34 - Pathways
2:39 - Supplements
Further Reading and References:
NF-kB and Jak-STAT pathway suppression
Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways | Acta Biochimica et Biophysica Sinica | Oxford Academic
https://academic.oup.com/abbs/article/47/3/207/1754742
Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784227/
Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review - PubMed
https://pubmed.ncbi.nlm.nih.gov/32157749/
Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity1 | The Journal of Immunology | American Association of Immunologists
https://journals.aai.org/jimmunol/article/163/6/3474/32577/Curcumin-Blocks-Cytokine-Mediated-NF-B-Activation
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
Arachidonic Acid Pathway
Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537720/
MAPK Pathway
Omega-3 fatty acids mediated Cellular signaling and its regulation in Human Health - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S266726852300058X
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
,,-gsLxPagNB8,UCrtd2wePvAl6RN_D-9jWVQQ, Health,Knowledge, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_-gsLxPagNB8,What Are Reactive Oxygen Species and Lipid Species?
Let's understand the foundational components of inflammation reactive oxygen and reactive lipid species.
If you like this content and want more, I am doing a special membership offer. Click here:
https://www.drbeen.com/
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Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
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#drbeen #koolbeens #diabetes
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,,hRCac7xcAtg,UCrtd2wePvAl6RN_D-9jWVQQ, Health, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_hRCac7xcAtg,Erratum: Quercetin is primarily lipid soluble and weakly water soluble. I have put it in an incorrect category.
Which Antioxidants To Use Together?
As we use antioxidants for aches and pains/inflammation we need to keep in mind the water or lipid solubility of the molecule. Let's review.
If you like this content and want more, I am doing a special membership offer. Click here:
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Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
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#drbeen #koolbeens #diabetes
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,1,Simple Plan to Control Inflammation
Here is an important list of anti-inflammatory molecules to help manage inflammation.
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
Want to support this work?:
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#drbeen #Inflammation #Supplements
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References:
Visit articles related to these topics and see the references at the end: https://www.drbeen.com/articles/category/chronic-inflammation/
,1,Vitamin D May Reduce Fiery Death of Cells and Resulting Severe Inflammation
Vitamin D receptor activation leads to reduced pyroptosis, and a shift towards autophagy and apoptosis. Let's review the mechanism of pyroptosis and the studies about vitamin D's role in preventing pyroptosis.
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#drbeen #Inflammation #VitaminD
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jun. 21 2024 16:18 PM
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793783/
Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0960076020303149
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904361/
Pyroptosis: mechanisms and diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-021-00507-5
Effects of Vitamin D3 Supplementation and Aerobic Training on Autophagy Signaling Proteins in a Rat Model Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535215/
Apoptosis Induced by Vitamin D Compounds in Breast Cancer Cells Is Inhibited by Bcl-2 but Does Not Involve Known Caspases or p531 | Cancer Research | American Association for Cancer Research
https://aacrjournals.org/cancerres/article/59/19/4848/505530/Apoptosis-Induced-by-Vitamin-D-Compounds-in-Breast
Morphological Features of Organelles during Apoptosis: An Overview - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972681/
,1,Omega-3 Reduces Chronic Inflammation and Neurosurgical Pain
Two studies demonstrating the power of omega-3 to reduce inflammation and neurosurgical pain.
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
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PayPal: https://paypal.me/mobeensyed?locale.x=en_US
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#drbeen #koolbeens #Health #omega3
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Reference:
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - PubMed https://pubmed.ncbi.nlm.nih.gov/16531187/
An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/
Study Details | Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects | ClinicalTrials.gov https://clinicaltrials.gov/study/NCT01154478
Table - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/table/molecules-26-03369-t001/
University of Naples Federico II - Wikipedia https://en.wikipedia.org/wiki/University_of_Naples_Federico_II
,1,Understanding Inflammatory Pathways and How Supplements Can Help
In this video, we dive into the fascinating world of inflammation and explore the main pathways that play a crucial role in the body's response to injury or infection. We discuss the:
My article capturing this information: https://www.drbeen.com/articles/understanding-inflammatory-pathways-and-how-supplements-can-help/
Following pathways and supplements to modulate these are presented in this talk:
Arachidonic Acid Pathway
JAK-STAT Pathway
MAPK Pathway
NF-κB Pathway
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
My substack: https://mobeensyedmd.substack.com/
#drbeen #koolbeens #HealthPolicy
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Timestamps:
0:00 - Introduction to Inflammatory Pathways
0:34 - Pathways
2:39 - Supplements
Further Reading and References:
NF-kB and Jak-STAT pathway suppression
Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways | Acta Biochimica et Biophysica Sinica | Oxford Academic
https://academic.oup.com/abbs/article/47/3/207/1754742
Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784227/
Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review - PubMed
https://pubmed.ncbi.nlm.nih.gov/32157749/
Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity1 | The Journal of Immunology | American Association of Immunologists
https://journals.aai.org/jimmunol/article/163/6/3474/32577/Curcumin-Blocks-Cytokine-Mediated-NF-B-Activation
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
Arachidonic Acid Pathway
Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537720/
MAPK Pathway
Omega-3 fatty acids mediated Cellular signaling and its regulation in Human Health - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S266726852300058X
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
