Mitochondria and Aging
In this amazing study the researchers provide the evidence that mitochondrial membrane permeability plays an important role in cell senescence and death. We will use these concepts for the next series about Taurin. Let's review at a high level the study about mitochondria and aging.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jan. 19 2024 14:13 PM
Aging? Blame your mitochondria - Science in the News
https://sitn.hms.harvard.edu/flash/2023/aging-blame-your-mitochondria/
Apoptotic stress causes mtDNA release during senescence and drives the SASP | Nature
https://www.nature.com/articles/s41586-023-06621-4#Sec8
Mitochondrial dysfunction in cell senescence and aging - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246372/
Mitochondrial and metabolic dysfunction in ageing and age-related diseases | Nature Reviews Endocrinology
https://www.nature.com/articles/s41574-021-00626-7
Pleiotropic effects of mitochondria in aging | Nature Aging
https://www.nature.com/articles/s43587-022-00191-2
Bax, Bak and beyond - mitochondrial performance in apoptosis - PubMed
https://pubmed.ncbi.nlm.nih.gov/28755482/
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166495/
,,-gsLxPagNB8,UCrtd2wePvAl6RN_D-9jWVQQ, Health,Knowledge, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_-gsLxPagNB8,What Are Reactive Oxygen Species and Lipid Species?
Let's understand the foundational components of inflammation reactive oxygen and reactive lipid species.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,,hRCac7xcAtg,UCrtd2wePvAl6RN_D-9jWVQQ, Health, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_hRCac7xcAtg,Erratum: Quercetin is primarily lipid soluble and weakly water soluble. I have put it in an incorrect category.
Which Antioxidants To Use Together?
As we use antioxidants for aches and pains/inflammation we need to keep in mind the water or lipid solubility of the molecule. Let's review.
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Disclaimer:
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,1,Simple Plan to Control Inflammation
Here is an important list of anti-inflammatory molecules to help manage inflammation.
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#drbeen #Inflammation #Supplements
Disclaimer:
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References:
Visit articles related to these topics and see the references at the end: https://www.drbeen.com/articles/category/chronic-inflammation/
,1,Vitamin D May Reduce Fiery Death of Cells and Resulting Severe Inflammation
Vitamin D receptor activation leads to reduced pyroptosis, and a shift towards autophagy and apoptosis. Let's review the mechanism of pyroptosis and the studies about vitamin D's role in preventing pyroptosis.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jun. 21 2024 16:18 PM
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793783/
Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0960076020303149
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904361/
Pyroptosis: mechanisms and diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-021-00507-5
Effects of Vitamin D3 Supplementation and Aerobic Training on Autophagy Signaling Proteins in a Rat Model Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535215/
Apoptosis Induced by Vitamin D Compounds in Breast Cancer Cells Is Inhibited by Bcl-2 but Does Not Involve Known Caspases or p531 | Cancer Research | American Association for Cancer Research
https://aacrjournals.org/cancerres/article/59/19/4848/505530/Apoptosis-Induced-by-Vitamin-D-Compounds-in-Breast
Morphological Features of Organelles during Apoptosis: An Overview - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972681/
,1,Omega-3 Reduces Chronic Inflammation and Neurosurgical Pain
Two studies demonstrating the power of omega-3 to reduce inflammation and neurosurgical pain.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Reference:
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - PubMed https://pubmed.ncbi.nlm.nih.gov/16531187/
An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/
Study Details | Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects | ClinicalTrials.gov https://clinicaltrials.gov/study/NCT01154478
Table - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/table/molecules-26-03369-t001/
University of Naples Federico II - Wikipedia https://en.wikipedia.org/wiki/University_of_Naples_Federico_II
,1,A Chinese saying goes, "There's no pleasure in eating without meat." And the data backs that up: every year, China consumes 26 percent of the world's meat and 45 percent of its seafood — numbers that could grow alongside rising incomes. Impact investor Tao Zhang shows why getting Chinese consumers to switch to plant-based alternatives is vital to tackling climate change and explores how it's also a massive business opportunity to bring tasty, affordable new proteins to market.
Countdown is TED's global initiative to accelerate solutions to the climate crisis. The goal: to build a better future by cutting greenhouse gas emissions in half by 2030, in the race to a zero-carbon world. Get involved at https://countdown.ted.com/sign-up
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The TED Talks channel features talks, performances and original series from the world's leading thinkers and doers. Subscribe to our channel for videos on Technology, Entertainment and Design — plus science, business, global issues, the arts and more. Visit https://TED.com to get our entire library of TED Talks, transcripts, translations, personalized talk recommendations and more.
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https://youtu.be/647itg-A_aw
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,1,Tomorrow's primary marks a critical moment for Republicans resisting Donald Trump's nomination.
Former congressman Joe Walsh, is a seasoned campaigner familiar with New Hampshire's political landscape and led an anti-Trump Republican bid in 2020. Walsh shares insights with Christian Bryant on the potential impact of another Trump v. Biden showdown.
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,1,Mitochondria and Aging
In this amazing study the researchers provide the evidence that mitochondrial membrane permeability plays an important role in cell senescence and death. We will use these concepts for the next series about Taurin. Let's review at a high level the study about mitochondria and aging.
If you like this content and want more, click here: https://www.drbeen.com/
Want to support this work?:
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
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#drbeen #koolbeens #Longevity
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jan. 19 2024 14:13 PM
Aging? Blame your mitochondria - Science in the News
https://sitn.hms.harvard.edu/flash/2023/aging-blame-your-mitochondria/
Apoptotic stress causes mtDNA release during senescence and drives the SASP | Nature
https://www.nature.com/articles/s41586-023-06621-4#Sec8
Mitochondrial dysfunction in cell senescence and aging - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246372/
Mitochondrial and metabolic dysfunction in ageing and age-related diseases | Nature Reviews Endocrinology
https://www.nature.com/articles/s41574-021-00626-7
Pleiotropic effects of mitochondria in aging | Nature Aging
https://www.nature.com/articles/s43587-022-00191-2
Bax, Bak and beyond - mitochondrial performance in apoptosis - PubMed
https://pubmed.ncbi.nlm.nih.gov/28755482/
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166495/
,1,Full Measure is a weekly Sunday news program focusing on investigative, original and accountability reporting. The host is Sharyl Attkisson, five-time Emmy Award winner and recipient of the Edward R. Murrow award for investigative reporting. She is backed by a team of award winning journalists.
Each week, we have a cover story that explores untouchable topics in a fearless way including: immigration, terrorism, government waste, national security and whistleblower reports on government and corporate abuse and misdeeds.
Full Measure is broadcast to 43 million households in 79 markets on 162 Sinclair Broadcast Group stations, including ABC, CBS, NBC, FOX, CW, MyTV, Univision and Telemundo affiliates. It also streams live Sunday mornings at 9:30 a.m. ET.
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,1,(24 Jan 2024) Scientists studying these emperor penguins - considered “near threatened” with extinction - say they've spotted four previously unknown colonies. (Jan 24).
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,1,Pancreatic Cancer Vaccines With Amazing Results in Phase I
Pancreatic ductal adenocarcinoma is one of the most lethal cancers with a 5 year survival rate of less than 10%. mRNA designer/personalized vaccines are changing this situation. Let's review the results of phase I trials.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Tuesday, Jun. 4 2024 11:37 AM
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches | Radiation Oncology | Full Text
https://ro-journal.biomedcentral.com/articles/10.1186/s13014-019-1345-6
NHS England Thousands of NHS patients to access trials of personalised cancer ‘vaccines’
https://www.england.nhs.uk/2024/05/thousands-of-nhs-patients-to-access-trials-of-personalised-cancer-vaccines/
Three-year Phase 1 Follow-Up Data for mRNA-based Individualized Immunotherapy Candidate Show Persistence of Immune Response and Delayed Tumor Recurrence in Some Patients with Resected Pancreatic Cancer | BioNTech
https://investors.biontech.de/news-releases/news-release-details/three-year-phase-1-follow-data-mrna-based-individualized
Investigational mRNA Vaccine Induced Persistent Immune Response in Phase 1 Trial of Patients With Pancreatic Cancer | Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out
Trial Design
https://www.biontech.com/int/en/home/pipeline-and-products/clinical-trials-new/trial-design.html
Cancer vaccines are having a renaissance | MIT Technology Review
https://www.technologyreview.com/2024/05/03/1092026/cancer-vaccines-are-having-a-renaissance/
NHS England launches scheme to boost signups for personalised cancer vaccine trials | The BMJ
https://www.bmj.com/content/385/bmj.q1212#:~:text=The%20vaccines%20currently%20being%20trialled,identify%20and%20destroy%20cancer%20cells.
,1,We just got an introduction to modern political philosophy, so let's continue by looking at some additional important figures approaching the contemporary era. These are Mary Wollstonecraft, Jeremy Bentham, John Stuart Mill, and Karl Marx. This was a time when humanist ideas began to shape society, as marginalized groups began to seek rights, and critiques of capitalism arose. How did these figures come up with the ideas that would underscore much of the changes to come in the 20th century?
Script by Luca Igansi
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,1,This footage shows the moment Ukraine drone pilots destroyed Russian positions with explosives.
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Gary Brecka is a Human Biologist, ‘Biohacker’ and co-founder of 10X Health System. Formerly a mortality researcher for the insurance industry, he now uses his experience to help people optimise the mind, body and spirit through modern science. His system has been credited with changing many lives, including that of UFC president, Dana White.
#science #health #wellness
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Stand-up comedians Konstantin Kisin (@konstantinkisin) and Francis Foster (@francisjfoster) make sense of politics, economics, free speech, AI, drug policy and WW3 with the help of presidential advisors, renowned economists, award-winning journalists, controversial writers, leading scientists and notorious comedians.
,1,The doors are shuttered at Water's Edge in Bensalem, but checks for future parties to be hosted at the venue have already been cashed.
Those who were looking forward to celebrating major life milestones at the venue are now looking for their money back.
"All she wanted to do is walk down the aisle in a dress and have her dad give her away. And they took it from us," said Stephen Dixon.
Instead, Dixon and his finance Kayla Kilpatrick say they are out a $4,300 deposit for their upcoming June 3 wedding. They are also left without a venue.
#wedding https://6abc.com/waters-edge-wedding-venue-benslem-pa-closed-deposits/12131087/
,1,Subscribe to Hotboxin' with Mike Tyson - http://bit.ly/38GAYR5
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,1,Legendary conductor Benjamin Zander explains his view on the difference between "positive thinking" and "possibility" (one's a fraud; the other's the real thing, he says) and intersperses delightful stories from a lifetime in music with a sing-along to Beethoven's Symphony No. 9.
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https://youtu.be/xKBl8XwL9qg
TED's videos may be used for non-commercial purposes under a Creative Commons License, Attribution–Non Commercial–No Derivatives (or the CC BY – NC – ND 4.0 International) and in accordance with our TED Talks Usage Policy: https://www.ted.com/about/our-organization/our-policies-terms/ted-talks-usage-policy. For more information on using TED for commercial purposes (e.g. employee learning, in a film or online course), please submit a Media Request at https://media-requests.ted.com
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,1,President Donald Trump was met with loud, sustained boos and chants of "Lock him up!" from fans at Nationals Park when he was shown on the in-stadium video screen after the third inning of Game 5. The boos ended only after the video screen cut to a shot of U.S. service members waving to the crowd and then showed a message thanking the military. Trump is attending the game with five wounded veterans. READ MORE: https://6abc.com/sports/nationals-park-fans-boo-president-trump-chant-lock-him-up/5652116/
